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Decline in HRT Use Linked to Drop in Breast Cancer


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Berry said the Emory researchers looked at other potential causes for the decline in breast cancer rates, including whether fewer women were getting screening mammograms to detect tumors. The researchers also checked for environmental factors and the use of breast cancer drugs such as tamoxifen and raloxifene. But none of these factors had changed significantly enough to cause such a drop in breast cancer rates, the study authors said.

The breast cancer rates leveled off by 2004, to rates not seen since 1987, the study authors said.

"Overall, this is very encouraging news," said Dr. Julia Smith, director of the New York University Cancer Institute Breast Cancer Screening and Prevention Program in New York City.

Text Continues Below



However, Smith said she'd like to know if this drop will affect survival rates in the future. "Have these cancers been eliminated, or are they just below our level of detection now, but will rise up again?" she asked.

Both Berry and Smith pointed out that if a woman is suffering through menopausal symptoms, such as hot flashes, short-term use of hormone replacement therapy is likely safe.

"You can give low-dose HRT for short periods of time for women who really have a quality-of-life issue," Smith said. She added that individual risk needs to be assessed on a case-by-case basis, but even some women at high risk of breast cancer may be able to use HRT for short-term relief.

"It doesn't make sense to do something in the name of prevention and protection -- (withholding HRT) -- that ends up hurting the person," Smith said.

Berry said: "If you're taking HRT for long-term health effects, it's not worth it. But, if you're taking HRT for menopausal symptoms and it works for you, it's probably a reasonable thing to continue. I'd stop it occasionally to see if the hot flashes are still there, but short-term use for a year or two probably won't affect your risk in the long run."

More information

To learn more about preventing breast cancer, visit the American Cancer Society.

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Copyright © 2007 ScoutNews, LLC. All rights reserved.
Last updated 4/19/2007

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SOURCES: Donald Berry, Ph.D., chairman, department of biostatistics, The University of Texas M.D. Anderson Cancer Center, Houston; Julia Smith, M.D., Ph.D., director, New York University Cancer Institute Breast Cancer Screening and Prevention Program, and director, Lynne Cohen Breast Cancer Preventive Care Program, New York University Cancer Institute and Bellevue Hospital, New York City; April 19, 2007, New England Journal of Medicine; April 19, 2007, online The Lancet


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