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Page: << Prev | 1 | 2 There was also a greater reduction in risk for tumors that were both progesterone- and estrogen-receptor positive, than for tumors which were estrogen-receptor positive and progesterone-receptor negative.
Women in the tamoxifen group also had more side effects, including hot flashes and heart problems. These are noted side effects of the drug. A woman's cardiac risk needs to be assessed before she is started on tamoxifen, the authors stated.
The new study "reaffirms the pioneering work that the NSABP did back in the '90s," Brooks said. "Tamoxifen is still an excellent drug for prevention of breast cancer and is underutilized," he added.
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Another expert said newer drugs can help, too.
"Tamoxifen does decrease the risk of invasive breast cancer," said Dr. Alison Estabrook, chief of breast surgery at St. Luke's-Roosevelt Hospital in New York City. "We're hoping that the new aromatase inhibitors which are being tried now for prevention will reduce the risk of breast cancer, which they should."
Aromatase inhibitors, which lower the amount of estrogen in the body by blocking a key enzyme, have far fewer side effects than tamoxifen. Another drug, raloxifene, also has fewer side effects but does not prevent noninvasive breast cancer, whereas tamoxifen works on both, Brooks said.
In other findings, reported in the same issue of the journal, a team at Baylor College of Medicine in Houston used a three-drug combo to block the growth of aggressive breast cancers in mice.
The team added two cancer drugs, gefitinib and pertuzumab, to Herceptin (trastuzumab) to help slow the growth of tumors with higher levels of a protein called HER-2. Herceptin was designed to block HER-2 but proved much more effective with the addition of the other two agents, the researchers found.
A clinical trial will begin soon, said co-investigator Dr. Kent Osborne, director of the Breast Center and Dan L. Duncan Cancer Center at Baylor. "We are very excited to see if our laboratory results can be translated to patients with the more aggressive types of breast cancer," he said in a statement.
More information
There's more on tamoxifen at the U.S. National Cancer Institute.
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