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Obesity-Linked Woes Boost Kids' Lifetime Heart Risk


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To explore a possible link between pediatric metabolic syndrome and adult heart disease, Morrison and his team cross-referenced data for contributing syndrome characteristics collected from a pool of 771 children between 1973 and 1978, and then again between 2000 and 2004.

The participants were drawn from the Cincinnati region and were between the ages of 6 and 19 in the first study and 30 and 48 in the follow-up study. A little less than three-quarters of the pool were white and a little more than a quarter were black.

Patient blood samples were taken the time of study enrollment and then 25 years later. The researchers gauged blood pressure; body mass index (BMI); and cholesterol. Blood triglyceride and glucose levels were also assessed.

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The participants also reported any history of heart attack or stroke, or procedures such as coronary bypass or angioplasty.

Four percent of the participants -- 31 boys and girls -- had metabolic syndrome as children, while more than 25 percent had the condition 25 years later, the researchers reported.

Among those with pediatric metabolic syndrome, almost 70 percent still had the condition as adults, and almost 20 percent had gone on to develop cardiac disease in the intervening years.

In contrast, only 1.5 percent of the children who did not have the syndrome as kids went on to experience heart trouble as adults.

Furthermore, any rise or fall in BMI over the 25 years was linked to a concurrent rise or fall in risk for developing the metabolic syndrome. In that time frame, every BMI bump or drop of 10 points translated into a 24 percent risk increase or decrease for the syndrome, the team reported.

Morrison and his colleagues said their findings should help doctors and parents identify young patients who are at an increased risk for serious adult illness. They could also point the way toward ways to reduce that risk.

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Copyright © 2007 ScoutNews, LLC. All rights reserved.
Last updated 8/10/2007

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SOURCES: John A. Morrison, Ph.D., research professor, pediatrics and division of cardiology, Cincinnati Children's Hospital Medical Center, Ohio; Brenda Kohn, M.D., associate professor, pediatrics, New York University School of Medicine, New York City, and member, medical advisory board, Juvenile Diabetes Foundation; August 2007, Pediatrics


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