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Two Parents With Alzheimer's Raises Child's Risk


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"The real value of this approach may be that additional and larger studies will allow us to find these weaker genetic risk factors as they act in concert to cause Alzheimer's and perhaps any environmental factors that are able to counteract them," Cole said. "Is there more than luck to the secret of the children who inherit risk of Alzheimer's disease from both parents and yet manage to escape the disease?" he wondered.

Another expert wasn't surprised by the findings.

"This new paper documents that the children of two affected parents do indeed have risks higher than the general population, as expected," said Dr. Sam Gandy, chairman of the National Medical and Scientific Advisory Council of the Alzheimer's Association.

Text Continues Below



"Plus, the paper goes on to provide direct support for the existence of an 'additivity' of the risk of each of the two parents. For children of two parents with Alzheimer's, these data provide direct evidence that their risk of developing dementia is nearly one in two," Gandy said.

More information

For more information on Alzheimer's disease, visit the Alzheimer's Association.

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Copyright © 2008 ScoutNews, LLC. All rights reserved.
Last updated 3/10/2008

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SOURCES: Thomas D. Bird, M.D., professor, neurology, University of Washington School of Medicine, Seattle; Sam Gandy, M.D., Ph.D., chairman, National Medical and Scientific Advisory Council, Alzheimer's Association; Greg M. Cole, Ph.D., neuroscientist, Greater Los Angeles VA Healthcare System, and associate director, Alzheimer's Disease Research Center, University of California, Los Angeles, David Geffen School of Medicine; March 2008 Archives of Neurology


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