Schizophrenia Tied to Multiple Genetic Errors

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"The idea that multiple rare mutations may account for a substantial portion of the incidence of schizophrenia is at variance with the current dogma of the field, which is that a number of mildly deleterious, common alleles [genes] combine with environmental factors to lead to the development of schizophrenia," Holt said.

"I believe that this study could lead to a change in the overall direction of the field, and I look forward to further replication and extension of these findings," Holt said.

According to the National Institute of Mental Health, schizophrenia affects about 1.1 percent of the adult American population in a given year. People with schizophrenia sometimes hear voices others don't hear, believe that others are broadcasting their thoughts to the world, or become convinced that others are trying to harm them. These experiences can make them fearful and withdrawn and make it difficult to have relationships with other people.

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For more on schizophrenia, visit the U.S. National Institute of Mental Health.

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