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Taking Depression to Heart


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The study found that depressive symptoms, but not anxiety and anger, were associated with greater thickening of the arteries over time. Further analyses indicated that only the physical symptoms of depression were associated with thickening arteries, while the cognitive and emotional symptoms of depression, such as sadness, pessimism, and indecisiveness, were not related.

Scientists have not yet established whether depression causes heart disease or whether some other factor, such as diet, affects depression and heart disease. In a review of the epidemiologic data, published in 2007, Dr. Francois Lesperance, a professor in the Department of Psychiatry at the University of Montreal in Canada, noted that the evidence supports each theory.

While it might be useful to identify depression as a marker for future heart trouble, it's still not a proven tool. "No secondary prevention trial has successfully reduced cardiovascular risk by targeting depression," Lesperance wrote.

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Robert M. Carney, a professor of psychiatry and director or the Behavioral Medicine Center at Washington University School of Medicine in St. Louis, agreed. "There currently exists no evidence that treating depression will help prevent heart disease," he said. "The biggest reason is that studies that would be needed to draw that conclusion would have to be large and therefore very expensive."

Still, Carney thinks it's important for patients to know that depression is a risk factor for developing heart disease. What's more, the potential benefits of recognizing and treating depression, such as improved quality of life, are well known and sufficient reason to get treatment, he noted. "Hopefully, an added bonus will be to reduce the risk of developing or suffering from heart disease," he said.

Stewart is planning other studies examining the relationships between depression and hostility, and various measures of cardiovascular risk. He also plans to investigate whether positive emotions -- happiness, for example -- and related factors, such as optimism, are associated with reduced cardiovascular risk and therefore protective against heart disease.

"Ultimately, we plan to use the data from this study and similar investigations to develop a psychological treatment for adults at risk for cardiovascular disease," Stewart said. "We hope that our treatment, when combined with standard treatments, will help to prevent the development of cardiovascular disease."

More information

For more on depression and related health risks, visit the National Institute of Mental Health.

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Copyright © 2008 ScoutNews, LLC. All rights reserved.
Last updated 8/1/2008

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SOURCES: Jesse C. Stewart, Ph.D., assistant professor, department of psychology, Indiana University-Purdue University, Indianapolis; Robert M. Carney, Ph.D., professor, psychiatry, and director, Behavioral Medicine Center, Washington University School of Medicine, St. Louis; American Academy of Family Physicians; February 2007 Archives of General Psychiatry; February 2007 Cleveland Clinic Journal of Medicine


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