Ibuprofen No Better at Reducing Alzheimer's Risk

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Overall, people who regularly took NSAIDs had a 23 percent lower risk of developing Alzheimer's. But there didn't appear to be any difference in the effectiveness of the different types of NSAIDs.

And ibuprofen, a commonly used SALA, was no more or less effective than naproxen, a commonly used non-SALA, Zandi said.

The findings do cast doubt on the theory that NSAIDs may help prevent Alzheimer's by reducing production of A beta 42, he said.

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"That leaves a conundrum, a scientific mystery," Zandi said. "What's very clear is that observational data is very consistent, that there is a reduction in risk among people using NSAIDs, so there's something going on."

What exactly is going on, however, is unclear.

"The question of anti-inflammatory drugs being used as a protective mechanism against Alzheimer's has been investigated for over a decade now," said Maria Carrillo, director of medical and scientific relations at the Alzheimer's Association in Chicago. "We know that there have been some controversial results out there, so currently what we also know is that they [NSAIDs] are not approved for the treatment or prevention of Alzheimer's disease. The Alzheimer's Association does not recommend you take NSAIDs on a daily basis because there are a lot of side effects... The jury is still out on whether NSAIDs can be protective against Alzheimer's."

More information

Visit the Alzheimer's Association for more on this condition.

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