Arsenic in Drinking Water Raises Diabetes Risk

Even low levels, like those found in U.S., could boost the odds, study finds

By Amanda Gardner
HealthDay Reporter

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TUESDAY, Aug. 19 (HealthDay News) -- High levels of arsenic in urine may be linked with a higher risk of developing type 2 diabetes, researchers report.

The findings, published in the Aug. 20 issue of the Journal of the American Medical Association, are the first to link low-level exposure to arsenic with type 2 diabetes prevalence in the United States.

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"This suggests that arsenic would play a role in the development of diabetes," said lead researcher Dr. Ana Navas-Acien, assistant professor of environmental health science at the Bloomberg School of Public Health at Johns Hopkins University. "But there clearly needs to be additional research conducted because our study has certain limitations. We are conducting those studies now, but that's going to take a few years."

"This is a good base for future research but it's a small sample size and doesn't look at dose-response," added Rajat Sethi, assistant professor of pharmaceutical sciences with the Texas A&M Health Science Center's Irma Lerma Rangel College of Pharmacy, in Kingsville. "A lot of research still needs to be done."

Inorganic arsenic from natural mineral deposits contaminates much drinking water. Individuals exposed to enough arsenic can develop cancer, among other conditions, experts note.

According to background information in the study, about 13 million people in the United States live in areas with a concentration of inorganic arsenic in the public water supply that exceeds recommended levels.

In animal studies, high concentrations of arsenic affected glucose and insulin mechanism -- key factors in type 2 diabetes.

And, epidemiologic studies in Taiwan, Bangladesh and Mexico, which have relatively high levels of inorganic arsenic in drinking water, have associated arsenic with the development of diabetes.

It's unclear, however, if lower levels of arsenic might have a similar effect. In areas such as Taiwan and Bangladesh, arsenic levels in drinking water are above 100 micrograms per liter, while in the United States the safety standard is only 10 micrograms per liter.

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