'Abuse-Resistant' Form of OxyContin May Be Near

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Dissolving control-release OxyContin tablets in alcohol is one way users bypass the time-control mechanism to deliver the drug immediately, a tactic called "dose dumping."

But Remoxy is designed to thwart that tactic, depriving the user of the quick high he or she seeks.

For the first study, 37 volunteers ingested one Remoxy 40 milligram tablet while drinking 240 milliliters of either water alone, a four-percent ethanol (alcohol) mixture, a 20-percent ethanol mixture or a 40-percent ethanol mixture.

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Even combining Remoxy with up to 40 percent ethanol did not interrupt the drug's controlled-release mechanism, the researchers report.

A second paper essentially found that the new formulation relieves pain as it should.

In the study, 412 patients with moderate-to-severe osteoarthritis pain of the hip or knee were randomized to receive either Remoxy or a placebo over the course of 12 weeks.

Those participants taking Remoxy reported lower pain intensity scores as compared to participants on the placebo.

"This shows that Remoxy does control moderate-to-severe pain," Friedman noted.

According to the researchers, the study is the first such trial to demonstrate the effectiveness of any twice-daily formulation of oxycodone over three months in patients with chronic pain.

More information

The Substance Abuse and Mental Health Services Administration has more on OxyContin abuse.

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