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Page: << Prev | 1 | 2 The researchers found no statistically significant differences between the two groups using measures such as the duration of hospitalization and the need for additional medications.
"Our study provides robust evidence that a short course of oral steroids has no clinical benefit, at least for children with mild to moderately severe [wheezing] attacks," said study senior author Dr. Jonathan Grigg, a professor of pediatric respiratory and environmental medicine at Queen Mary University London.
But, Grigg added, "doctors may still prescribe a course [of oral steroids] on a case-by-case basis, especially in severe attacks."
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The second study included 129 children between the ages of 1 and 6 who were randomly assigned to receive 750 micrograms of inhaled fluticasone proprionate twice daily or a placebo. Fluticasone proprionate is an inhaled steroid and is often used as a preventive medication for people with asthma. In this study, the children were given the medication or placebo at the onset of any upper respiratory infection and asked to continue the medication for a maximum of 10 days. They did this over a period of six to 12 months.
Unlike the first study, the researchers did see a slight benefit from using the preventive inhaled steroid medication, but there were also side effects, such as a smaller gain in height and weight, that probably outweighed those benefits.
"These kids have intermittent wheezing with a respiratory virus, with no wheezing in between. Maybe viral-induced wheezing isn't so much inflammation, but an irritability of the airways, so anti-inflammatories [like steroids] don't work. Maybe it's a different pathophysiology with similar symptoms. Not all wheezing is asthma in kids," Appleyard suggested.
She did point out that the findings from these studies don't apply to children with asthma, and that these medications can be very helpful in children with asthma. Children with asthma will wheeze at other times, not just when they have a virus, Appleyard noted.
More information
To learn more about available asthma treatments and how they work, visit the U.S. National Heart, Lung, and Blood Institute.
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