Folic Acid Supplements Raise Prostate Cancer Risk

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That study of folate intake and prostate cancer "found that it really didn't have much effect," Stevens said. "Our study actually suggested that folate might be protective for men with advanced prostate cancer, a group that wasn't included in this study."

Overall, "it's a pretty complicated picture," Stevens said. "Previous epidemiological evidence suggests that not having enough folate can be bad, but having an excess might not be good. You need to have adequate folate nutrition. But it doesn't get better if you have more, and it may get worse."

The study is the latest to throw cold water on the hope that supplements can reduce the risk of cancer. Two studies reported late last year that supplements containing selenium, vitamin E and vitamin C had no effect on the incidence of prostate cancer.

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One of those studies included more than 35,000 men aged 50 and over who were followed for more than five years, and the other included almost 15,000 male physicians aged 50 and over who were followed for an average of eight years.

"It is safe to conclude that cancer prevention is not going to be as simple as recommending high-dose micronutrient supplements for middle-aged and older adults," said an editorial accompanying the latest report.

Detailed studies to understand how diet and supplements affect biological mechanisms of cancer in humans are needed, as well as large-scale epidemiological studies looking for ways in which diet can reduce risk, according to the editorial by Alan Kristal of the Fred Hutchinson Cancer Research Center in Seattle and Dr. Scott Lippman of the M.D. Anderson Cancer Center in Houston.

"There is no evidence that supplements of any type reduce cancer risk, and increasing evidence that they may increase the risk for some cancers in some people," said Kristal, who is a professor of epidemiology and associate director of the cancer prevention program at Fred Hutchinson. "The only exception is calcium for recurrence of colorectal polyps, where there is solid evidence that calcium can reduce risk."

More information

Learn about prostate cancer prevention from the U.S. National Cancer Institute.

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