Blue Dye Halts Worsening Paralysis in Animal Study

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In the search for a compound that would thwart ATP attacks and could be administered intravenously, Nedergaard stumbled upon BBG.

An intravenous injection of BBG significantly reduced secondary injury in spinal cord-injured rats, which improved to the point of being able to walk again, although with a limp. There was a side effect, however. Injected rats had a blue tinge to their skin for a while.

While more study is needed, Nedergaard and longtime collaborator Dr. Steven Goldman, chair of the University of Rochester Department of Neurology, hope that BBG and related agents will yield new treatments for acute spinal cord injuries.

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More information

The U.S. National Institutes of Health offers information on spinal cord injuries.

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--Dennis Thompson