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Page: << Prev | 1 | 2 Giving the PPIs in combination with anti-clotting drugs did not increase the risk of death, heart attack, or stroke, the researchers concluded.
"We did not find use of a PPI to be associated with a higher risk of cardiovascular events for patients taking either clopidogrel or prasugrel," O'Donoghue said.
Dr. Dirk Sibbing, from the Technische Universitat Munchen in Germany and co-author of an accompanying commentary, said this study shows that PPIs affect the anti-clotting drugs, but not patient outcomes.
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"It seems that patients who carry a risk profile comparable to that of patients enrolled in TRITON-TIMI 38 can be safe on PPI treatment as long as compliance to regular anti-platelet drug intake is well-controlled," Sibbing said.
However, cautions should remain for high-risk patients and those who are less responsive to Plavix, Sibbing said. Also, he said he believes that for some patients taking Effient and PPIs, the combination may be harmful, he said.
"In any case, monitoring of compliance to anti-platelet treatment is mandatory in all patients, but specifically in the group of patients under concomitant PPI treatment," Sibbing said.
"Specific studies, however, are warranted in this group of patients to clarify this issue," he said.
O'Donoghue doesn't disagree. "In the end, only a randomized clinical trial can definitively demonstrate the safety of combining these two classes of drugs," she said.
More information
For more information on heart attacks, visit the U.S. National Heart, Lung, and Blood Institute.
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