Pregnancy May Protect Breast Cancer Survivors

Finding important because more women are delaying motherhood, researchers say

By Amanda Gardner
HealthDay Reporter

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THURSDAY, March 25 (HealthDay News) -- New research suggests that women who become pregnant after having had breast cancer may actually improve their survival odds, a notion contrary to what some medical experts had thought.

The finding is significant, given that the death rate from breast cancer is on the decline and more women are delaying pregnancy until later in life, the study authors said.

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The new study joins two others looking at breast cancer and pregnancy, all of which are being presented this week at the European Breast Cancer Conference, in Barcelona.

Women in their childbearing years are more likely to develop breast cancer than any other malignancy.

The first study was a meta-analysis of 14 prior trials -- published between 1970 and 2009 -- involving approximately 20,000 women with a history of breast cancer, some pregnant and some not.

The researchers, from Belgium, Greece and Italy, found that women who became pregnant following a breast cancer diagnosis had a 42 percent lower risk of dying than women with breast cancer who didn't get pregnant.

Why would this be the case?

Possibly hormones, the study authors speculated. Although estrogen is known to fuel breast cancer tumors, above a certain level, they can actually protect against the disease. Also, a mother produces antibodies during pregnancy that may be protective.

"This is the largest meta-analysis to confirm this, but this has been known from previous, smaller studies from major institutions," said Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, La.

Dr. Paul Tartter, senior attending physician at St. Luke's-Roosevelt Hospital's Comprehensive Breast Center in New York City, acknowledged that this was good news, but said "the average physician, including gynecologists, will still tell patients not to get pregnant after being treated for breast cancer. There's a tremendous mythology that we just can't shake."

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