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HPV Vaccine Has Higher Allergic Reaction Rate

But the overall risk for these events is still extremely low, experts note

By Randy Dotinga
HealthDay Reporter


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MONDAY, Sept. 1 (HealthDay News) -- The rate of serious allergic reactions to the cervical cancer vaccine is considerably higher than that for other vaccines given to children, but the total number of these reactions remains miniscule, Australian researchers report

Overall, the Gardasil shot is remarkably safe, declared a team of doctors in an editorial accompanying the study in the Canadian Medical Association Journal. They did acknowledge the need to keep tabs on possible side effects, however.

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"Parents can be reassured that these reactions were very rare and are not a reason to not vaccinate their daughter against HPV (the virus that causes cervical cancer)," said study lead author Dr. Julia Brotherton, a public health physician at the National Centre for Immunization Research and Surveillance in Australia.

Gardasil, which was approved for use in the United States in 2006, protects against the human papillomavirus, or HPV, a sexually transmitted infection that causes most cases of cervical cancer, as well as other conditions such as genital warts. The U.S. Centers for Disease Control and Prevention currently recommends that 11- and 12-year-old girls be targeted for this vaccine, as most girls of this age are not yet sexually active, have not yet been exposed to HPV, and will therefore achieve maximum protection.

The recommendation was not without controversy, with some parents objecting to the shot because they felt it might encourage sexual activity, or because they feared potential complications or side effects.

This study focused on anaphylaxis, or severe allergic reactions to the shot.

In 2007, Australia launched a government-funded vaccination program aimed at females aged 12 to 26. The study authors found a total of seven cases of allergic reactions out of almost 270,000 doses, a rate of 2.6 cases per 100,000 doses. (Patients are supposed to receive three doses of the vaccine in order to be protected.)

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Copyright © 2008 ScoutNews, LLC. All rights reserved.
Last updated 9/2/2008

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SOURCES: Julia Brotherton, M.D., public health physician, National Centre for Immunization Research and Surveillance, Westmead, New South Wales, Australia. Sept. 9, 2008, Canadian Medical Association Journal


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