Painkillers Lower PSA Test Readings

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"It is a trial that would go on for many years involving many men," Singer said.

NSAIDs reduce inflammation, and chronic inflammation has been linked to many malignancies, including prostate cancer. The cyclooxygenase enzymes, which are inhibited by NSAIDs, play an important role in inflammation.

"I would be very cautious about drawing any conclusion about what message men should take away from this study," said Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society. "We should not take aspirin or NSAIDs as protection against prostate cancer."

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The cause of the lower PSA levels is not clear, Lichtenfeld said. "Whether it is because the medicines have a positive effect in reducing the risk of prostate cancer or mask a possible sign of prostate cancer is unknown," he said.

Doctors should ask men about aspirin and NSAID use before PSA screening, Lichtenfeld said. "Doctors should ask patients about all their medications, prescription and over-the-counter," he said. "That conversation should always occur between health-care providers and their patients."

More information

Learn all about prostate cancer from the National Cancer Institute.

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