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Page: << Prev | 1 | 2 This study was commissioned by the U.S. Agency for Healthcare Research and Quality.
After analyzing findings from 45 previous studies, the authors concluded that premixed insulin analogues and premixed human insulin provided similar blood-sugar control.
The analogues seemed to be more effective in lowering post-meal glucose levels, they said.
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The premixed analogues also appeared to be more effective than long-acting insulin analogues and pills in decreasing hemoglobin A1c (a measure of blood-sugar control over time) and post-meal glucose levels.
On the other hand, premixed analogues appeared less effective than long-acting insulin, but better than oral pills, in decreasing fasting glucose levels.
"In terms of clinical practice, what it basically is saying is that if you want to replace premixed human insulin with premixed insulin analog, both seem to work pretty much the same," said Qayyum.
However, there will be individual patients who react differently to different formulations and may do better with long-acting insulin, for instance, he added.
Also, for individuals taking oral medications whose blood sugar is not well controlled, "premixed analogue is one option that can be looked at instead of titrating up or manipulating these oral diabetic agents," Qayyum said.
And, Qayyum emphasized, there is almost no data on how these benefits affect clinical outcomes, meaning the various, severe complications of diabetes such as death, blindness and kidney failure. Longer follow-up studies are needed to answer those questions, he said.
More information
There's more on type 2 diabetes at the American Diabetes Association.
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