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Page: << Prev | 1 | 2 Treatment with 5-tetradecyloxy-2-furoic acid (TOFA), an ACC inhibitor, resulted in a more than thousand-fold reduction in HCMV replication. And treatment with C75 (trans-4-carboxy-5-octyl-3-methylene-butyrolactone), an inhibitor of FAS, resulted in a more than 100-fold reduction in the virus' replication.
To see if the drugs would impact the replication of other enveloped viruses, the researchers measured the replication of influenza A in the presence of the same drug. They found similar reductions in replication.
"Recent studies have shown that fatty acid biosynthesis is important for the replication of diverse enveloped viruses," said Munger. "The replication of both hepatitis C and HIV, for example, has been linked recently with lipid synthesis, reinforcing our approach and its importance. Lastly, viral infection also clearly upregulates glycolysis, a marker for tumor growth, which is just the latest in the longstanding connection between viruses and cancer. Hopefully, our work will at some point provide insight into the metabolic manipulations seen in cancer as well."
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-- Krisha McCoy
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