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THURSDAY, Oct. 9 (HealthDay News) -- Artery-opening procedures can be safely done in some cases without using the anti-clotting drug heparin, reducing the risk of excess bleeding, Italian cardiologists report.
Participants in the trial were chosen carefully, according to a report in the Oct. 7 issue of the Journal of the American College of Cardiology by doctors at the University of Turin. The 700 people who had the procedure were in no immediate danger of a heart attack, had single blockages of a heart artery, and were already taking two clot-preventing drugs, aspirin and thienopyridine.
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The incidence of heart damage and bleeding events was lower in those who got no heparin, and there was a lower risk of death, heart attack, or blood vessel problems in that group, the report said, but it ended on a decided note of caution: The no-heparin approach "probably could not be applied to all patients, even stable ones, and certainly not to patients with complex lesions in acute coronary symptoms."
"Unless a large multi-center trial is performed that confirms these findings, this paper is not intended to provide false reassurance for an operator who decides to try this approach," the report concluded.
That caution is decidedly warranted, said Dr. Harold L. Dauerman, director of the cardiac catheterization laboratory at the University of Vermont, who wrote an accompanying editorial comment.
"It is an interesting approach to decrease bleeding complications beyond the usual level of pharmacological reduction we would use," Dauerman said. "But using absolutely no heparin at all is a really bold step and could be dangerous in the wrong situation."
The Italian cardiologists were careful to pick the lowest-risk participants for their trial, "and even in these low-risk patients, I was surprised that there were so few complications," he said.
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