New Diet Pill Doubles Weight Loss of Current Drugs

Tesofensine could replace gastric bypass surgery for some patients, researchers say

By Steven Reinberg
HealthDay Reporter

Related Encyclopedia • Abdominoplasty • Acidophilus • Ankle Sprains • Antioxidants More... Related Animations • What is Cholesterol? More... Related Healthscout Videos Nutrition and Cancer Nutrition and Osteoporosis Importance of Good Nutrition Critical Nutrition More... Related Drug Information • Klor-Con • Klor-Con ER More... Related News Articles • Failed Infection Control Ups Risk for Hepatitis • Tight Glucose Control Disappoints • Doctors Urged to Screen Diabetics for Sleep Apnea • Guidelines Unveiled for Treating Clogged Heart Arteries More...

WEDNESDAY, Oct. 22 (HealthDay News) -- A new diet drug, tesofensine, produces twice the weight loss of currently available obesity drugs, Danish researchers report.

"Tesofensine produces a weight loss of approximately 10 percent more than placebo and diet in obese patients," said lead researcher Dr. Arne Astrup, from the Department of Human Nutrition, Faculty of Life Sciences, at the University of Copenhagen. Other drugs produce only about 5 percent weight loss, Astrup noted.

Text Continues Below

---

This drug could replace the need for gastric bypass surgery in some obese patients. "There is an enormous gap between the existing weight-loss compounds and gastric surgery," Astrup said. "Tesofensine could close that gap. If you combine the drug with an effective diet, you could probably reach the 20 percent weight loss seen in gastric surgery."

"Tesofensine could compete with gastric surgery and be offered to those who are below the threshold for surgery or for patients who do not wish [to have] gastric surgery," Astrup said. "There are also patients who cannot tolerate gastric surgery."

The report was published in the Oct. 23 online issue of The Lancet.

For the study, Astrup's team conducted a phase II trial in which they randomly assigned 203 obese patients to receive three different daily doses of tesofensine or placebo. The participants were also put on a low-energy diet.

Among the 161 who completed the trial, those who received tesofensine lost more weight than those receiving placebo. Over 24 weeks, those receiving the lowest dose of tesofensine (0.25 milligrams) lost 14.7 pounds, while those taking 0.5 milligrams lost 25 pounds, and those taking the highest dose (1 milligram) lost 28 pounds. People receiving placebo lost less than 5 pounds.

The weight loss among people who took 0.5 or 1 milligram of tesofensine was double that of weight loss seen with the currently available diet drugs Acomplia (rimonabant) or Meridia (sibutramine), the researchers said.

Page:  1 | 2 | 3 | Next >>