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Gene Variants Behind Vulnerability to Yeast Infections
Small studies found two mutations in women who had recurring episodes
By Amanda Gardner
HealthDay Reporter
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WEDNESDAY, Oct. 28 (HealthDay News) -- Scientists have identified two genetic mutations that help account for the presence of recurring yeast infections in certain women.
Although the researchers focused their work on small and very specific populations with extreme conditions, the findings provide new insights into one of the most common and annoying maladies to afflict women.
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"This discovery is important as a starting point for further work," said Dr. Bart Jan Kullberg, co-author of one of two papers appearing in the Oct. 29 issue of the New England Journal of Medicine.
"It is the first proof in the area of fungal infections that subtle genetic differences exist that explain why some [apparently healthy] persons do get certain ailments, and even suffer from recurrent episodes, whereas others never acquire these infections," said Kullberg, a professor of medicine at Radboud University in Nijmegan, the Netherlands.
Although the people studied here had extreme conditions, "you could potentially move to other mutations in the [same] gene or in this pathway to give more subtle phenotypes that we might see in everyday medicine," said Dr. Anthony Gregg, director of maternal and fetal medicine and medical director of genetics at the University of South Carolina in Columbia.
Ultimately, researchers hope to use the findings to develop better treatments for these conditions, which become serious in some people.
"Once we understand the pathway, what we can potentially offer is therapies that take advantage of augmenting the normal pathways or utilizing redundant pathways that are working just fine but are not normally turned on to such a high degree," Gregg said.
At this point, however, the reports really have no relevance to patients, cautioned Dr. Steven Goldstein, a professor of obstetrics and gynecology at New York University Langone Medical Center in New York City.
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Copyright © 2009 ScoutNews, LLC. All rights reserved.
Last updated 10/28/2009
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SOURCES: Steven Goldstein, M.D., professor, obstetrics and gynecology, New York University Langone Medical Center, New York City; Anthony R. Gregg, M.D., board of directors, American College of Medical Genetics, and director, maternal and fetal medicine, and medical director, genetics, University of South Carolina, Columbia; Bart Jan Kullberg, M.D., professor, medicine, Radboud University Nijmegen, Nijmegen Institute for Infection, Inflammation, and Immunity, and chief, infectious diseases section, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands; Jeffrey Sands, Ph.D., professor and former chair, biological sciences, Lehigh University, Bethlehem, Pa.; Narendra Kumar, Ph.D., assistant professor, pharmaceutical sciences, Texas A&M Health Science Center Irma Lerma Rangel College of Pharmacy, Kingsville; Oct. 29, 2009, New England Journal of Medicine
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