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THURSDAY, Jan. 23 (HealthDayNews) -- A Dutch study finds what seems to be an unusual incidence of the eye cancer retinoblastoma among children conceived by in vitro fertilization (IVF), but experts are warning against alarm.
Between November 2000 and February 2002, five cases of retinoblastoma were diagnosed in children conceived by IVF in the Netherlands, says a report in Jan. 25 issue of The Lancet, and an analysis indicates that the risk of the cancer among IVF children might be five to seven times higher than in children conceived in the usual way.
But the finding "should be treated with caution," says a statement by the European Society of Human Reproduction and Embryology.
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"I do agree," adds Dr. Annette C. Moll, an epidemiologist at Vrije Universiteit Medical Center in Amsterdam who is the lead author of the journal report.
Moll says she would tell a couple considering IVF that "the small risk of retinoblastoma is increased, but it still remains a small risk."
IVF is used by couples who cannot have children because of conditions such as blocked fallopian tubes in a woman or very low sperm count in a man. One egg or several eggs are taken from the woman and are fertilized in a laboratory dish. The fertilized eggs are then implanted in the uterus. The success rate for the procedure is about 20 percent.
Retinoblastoma is a cancer of the retina whose usual rate of occurrence is 1 in 20,000. It is easily treated, with a success rate of 90 percent; the affected eye can be saved in four out of five cases. Treatment of all five of the affected children, who were between the ages of 8.5 months and 38 months, was successful, the journal report says.
The European Society of Human Reproduction and Embryology statement quotes Dr. Christina Bergh of Sahlgrenska Hospital in Sweden as saying she has "several concerns about the study."
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