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Muscle Fatigue Drug May Fight Heart Failure


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Plans are under way to test the drug at other medical centers in patients with heart failure to see if it relieves fatigue and improves heart function. Even if successful, it will take several years before the drug will be commercially available.

Fatigue experienced by heart failure patients does not stem from reduced blood and oxygen being supplied to the muscles by the heart, as one might expect. Instead, Marks' previous research in muscles of mice with heart failure suggested the cause is calcium leak in muscle cells, which reduce the ability of a single muscle to contract repeatedly before losing force.

"We then had a hunch that the process that produces fatigue in heart failure patients also may be responsible for the fatigue felt by athletes after a marathon or extreme training," study first author Andrew Bellinger said in a prepared statement. "Our new paper shows that fatigue in both patients and athletes probably stems from the same leak."

Text Continues Below



More information

The U.S. Centers for Disease Control and Prevention has more facts about heart failure.

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-- Kevin McKeever

Copyright © 2008 ScoutNews, LLC. All rights reserved.
Last updated 2/12/2008

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From Healthscout's partner site on heart disease, MyHeartCentral.com
Learn about heart disease symptoms.
Get more information on heart disease treatment for your health!
What can you do to prevent heart disease? Prevention details here.





SOURCE: Columbia University Medical Center, news release, Feb. 11, 2008


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