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New Worries Over Blockbuster Meds Avandia, Fosamax


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Again, the authors cautioned, risks and benefits should be carefully weighed when prescribing the drug.

Other studies have also reported atrial fibrillation as a side effect of bisphosphonates, the class of drugs that includes Fosamax.

Ronald Rogers, a spokesman for Fosamax manufacturer Merck & Co. Inc., called the Fosamax-fibrillation association an "old issue." He also pointed to an article published earlier this year in the British Medical Journal that found no such association.

Text Continues Below



Rogers also pointed out that the current study is an observational one and therefore subject to limitations not seen in a previous randomized trial. That trial saw an increase in the incidence of "serious" atrial fibrillation among Fosamax patients, he said, but it did not reach a statistically significant difference.

More information

There's more on type 2 diabetes at the American Diabetes Association.

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Last updated 4/28/2008

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SOURCES: Spyros G.E. Mezitis, M.D., Ph.D., endocrinology consultant and clinical investigator at Lenox Hill Hospital, and clinical assistant professor of medicine, NewYork-Presbyterian Hospital/Cornell Medical Center, New York City; Nancy Pekarek, spokeswoman, GlaxoSmithKline; Ronald Rogers, spokesman, Merck & Co. Inc.; April 28, 2008, Archives of Internal Medicine; March 11, 2008, British Medical Journal


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