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Celebrex, Naproxen Won't Prevent Mental Decline


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"Increasingly we see that if we're going to want to understand how the process of Alzheimer's disease begins in the brain, we cannot limit our studies simply to older adults," Morris said. "We have to begin to study people even in middle age because the disease process may have its origins decades before people actually develop it."

Dr. Gary Kennedy is director of geriatric psychiatry at Montefiore Medical Center in New York City. Regarding this particular area of anti-inflammatory research as it pertains to cognitive problems, he said, "It's not strike three, but it's strike two for sure. The inflammatory model was a reasonable shot to begin with, but it was a long shot. [Inflammation] may be a side effect."

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There's more on cognitive decline at the Alzheimer's Association.

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Last updated 5/12/2008

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SOURCES: Barbara K. Martin, Ph.D., assistant professor, epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore; John Morris, M.D., professor, neurology and director, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis and member, medical and scientific advisory council, Alzheimer's Association; Gary J. Kennedy, M.D., director, geriatric psychiatry, Montefiore Medical Center, New York City; July 2008, Archives of Neurology


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