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Gene Treatment in Mice Makes Old Liver Cells Young


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Most people who develop Parkinson's disease or Alzheimer's disease are born with a mutation that gives rise to defective proteins late in life, Cuervo said. Improving the cellular protein disposal systems in brain cells might delay the onset of the conditions, she said.

Genentic engineering might not be needed to achieve the anti-aging goal in humans, Cuervo said. "As we understand why this system decreases with aging, we are trying to identify compounds that do the same thing," she said. "Also, we are looking at dietary manipulation. Some modifications in the diet might do the same thing."

The findings were published Aug. 10 in the online issue of the journal Nature Medicine.

Text Continues Below



Dr. Ronald Klatz, president of the American Academy of Anti-Aging Medicine, called the new study "another piece of evidence supporting the contention that aging is a reversible condition. We can not only slow aging, but also reverse many forms of aging."

Klatz acknowledged a feeling of disappointment that genetic engineering was required to achieve the anti-aging effect in the test animals. But, he added, "From the pure science point of view, it is impressive."

More information

Learn about lysosome function from the U.S. National Library of Medicine.

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Copyright © 2008 ScoutNews, LLC. All rights reserved.
Last updated 8/11/2008

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SOURCES: Ana Maria Cuervo, M.D., associate professor of developmental and molecular biology, Albert Einstein Medical College, New York City; Ronald Klatz, D.O., president, American Academy of Anti-Aging Medicine, Chicago; Aug. 10, 2008, Nature Medicine, online


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