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The appearance of delta-8-cholestanol in plasma is consistent with inhibition of a late stage in cholesterol biosynthesis in these species. There also was a 25% reduction in cholesterol content of the outer cortex of the lens observed in a special study in quetiapine treated female dogs. Drug-related cataracts have not been seen in any other species; however, in a 1-year study in monkeys, a striated appearance of the anterior lens surface was detected in 2/ 7 females at a dose of 225 mg/ kg or 5.5 times the maximum recommended human dose on a mg/ m 2 basis. All trademarks are the property of the AstraZeneca group ©AstraZeneca 2001 AstraZeneca Pharmaceuticals LP Wilmington, DE 19850
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