Epogen

[Epoetin alfa]

Overdosage & Contraindications
CONTRAINDICATIONS

EPOGEN (r) is contraindicated in patients with:
1. Uncontrolled hypertension.
2. Known hypersensitivity to mammalian cell-derived products.
3. Known hypersensitivity to Albumin (Human).

OVERDOSAGE

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The maximum amount of EPOGEN (r) that can be safely administered in single or multiple doses has not been determined. Doses of up to 1500 Units/ kg TIW for 3 to 4 weeks have been administered to adults without any direct toxic effects of EPOGEN (r) itself.

Therapy with EPOGEN (r) can result in polycythemia if the hematocrit is not carefully monitored and the dose appropriately adjusted. If the suggested target range is exceeded, EPOGEN (r) may be temporarily withheld until the hematocrit returns to the suggested target range; EPOGEN (r) therapy may then be resumed using a lower dose (see DOSAGE AND ADMINISTRATION). If polycythemia is of concern, phlebotomy may be indicated to decrease the hematocrit.