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Women of childbearing potential who are candidates for anticoagulant therapy should be carefully evaluated and the indications critically reviewed with the patient. If the patient becomes pregnant while taking this drug, she should be apprised of the potential risks to the fetus, and the possibility of termination of the pregnancy should be discussed in light of those risks. Hemorrhagic tendencies or blood dyscrasias.
Recent or contemplated surgery of:
(1) central nervous system;
(2) eye;
(3) traumatic surgery resulting in large open surfaces. Bleeding tendencies associated with active ulceration or overt bleeding of: (1) gastrointestinal, genitourinary or respiratory tracts;
(2) cerebrovascular hemorrhage;
(3) aneurysms-cerebral, dissecting aorta;
(4) pericarditis and pericardial effusions;
(5) bacterial endocarditis. Text Continues Below
Threatened abortion, eclampsia and preeclampsia.
Inadequate laboratory facilities. Unsupervised patients with senility, alcoholism, or psychosis or other lack of patient cooperation. Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding. Miscellaneous: major regional, lumbar block anesthesia, malignant hypertension and known hypersensitivity to warfarin or to any other components of this product. OVERDOSAGE Signs and Symptoms: Suspected or overt abnormal bleeding (e. g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries) are early manifestations of anticoagulation beyond a safe and satisfactory level. Treatment: Excessive anticoagulation, with or without bleeding, may be controlled by discontinuing COUMADIN therapy and if necessary, by administration of oral or parenteral vitamin K 1 . (Please see recommendations accom-panying vitamin K 1 preparations prior to use.)
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