Enbrel

[etanercept]

Indications & Dosage
INDICATIONS AND USAGE

ENBRELŪ is indicated for reducing signs and symptoms, inducing major clinical response, inhibiting the progression of structural damage, and improving physical function in patients with moderately to severely active rheumatoid arthritis. ENBRELŪ can be initiated in combination with methotrexate (MTX) or used alone.

ENBRELŪ is indicated for reducing signs and symptoms of moderately to severely active polyarticular-course juvenile rheumatoid arthritis in patients who have had an inadequate response to one or more DMARDs.

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ENBRELŪ is indicated for reducing signs and symptoms and inhibiting the progression of structural damage of active arthritis in patients with psoriatic arthritis. ENBRELŪ can be used in combination with methotrexate in patients who do not respond adequately to methotrexate alone. ENBRELŪ is indicated for reducing signs and symptoms in patients with active ankylosing spondylitis.

ENBRELŪ is indicated for the treatment of adult patients (18 years or older) with chronic moderate to severe plaque psoriasis who are candidates for systemic therapy or phototherapy.

DOSAGE AND ADMINISTRATION

Adult RA, AS, and Psoriatic Arthritis Patients

The recommended dose of ENBRELŪ for adult patients with rheumatoid arthritis, psoriatic arthritis, or ankylosing spondylitis is 50 mg per week given as one subcutaneous (SC) injection using a 50 mg/mL single-use prefilled syringe. Methotrexate, glucocorticoids, salicylates,nonsteroidal anti-inflammatory drugs (NSAIDs), or analgesics may be continued during treatment with ENBRELŪ. Based on a study of 50 mg ENBRELŪ twice weekly in patients with RA that suggested higher incidence of adverse reactions but similar ACR response rates, doses higher than50 mg per week are not recommended (see ADVERSE REACTIONS).

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