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Enbrel

[etanercept]

PATIENT INFORMATION

ENBREL® (pronounced en-brel)Read these instructions carefully before you start taking ENBREL®. You should read this leaflet each time you get your prescription refilled, in case something has changed. The information in this leaflet does not take the place of talking with your doctor before you start taking this medication and at check-ups. Talk to your doctor if you have anyquestions about your treatment with ENBREL®.

What is ENBREL®?

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ENBREL® is a medicine for adults and children with moderate to severe forms of rheumatoid arthritis (RA) and a type of disease called psoriatic (sore-ee-ah-tick) arthritis. ENBREL® is also for adults with a type of arthritis called ankylosing spondylitis (ank-elow-sing spond-e-lie-tis) (AS). ENBREL® is also for adults with moderate to severe psoriasis (sore-I-ah-sis). RA, psoriatic arthritis, and AS are inflammatory diseases that affect the joints in your body. Psoriasis is an inflammatory disease that affects the skin and can cause raised, thick, red and scaly patches (“psoriatic skin lesions”) that can appear anywhere on the body. Psoriatic arthritis is usually seen in patients with psoriasis and affects both the joints and the skin.

How does ENBREL® work?

ENBREL® is a type of protein called a tumor necrosis factor (TNF) blocker that blocks the action of a substance your body makes called TNF-alpha. Tumor necrosis factor alpha is made by your body’s immune system. People with immune diseases like RA, psoriasis, and psoriatic arthritis, as well as patients with AS, have too much TNF-alpha intheir bodies, which can cause inflammation and lead to painful, swollen joints and raised,thick, red, scaly patches (“psoriatic skin lesions”) that can appear anywhere on the body. ENBREL® can reduce the amount of TNF in the body to normal levels, helping to treatjoint damage and skin lesions.

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