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Drug DescriptionSide Effects & Drug InteractionsWarnings & Precautions
Clinical PharmacologyOverdosage & ContraindicationsIndications & Dosage

Norvasc

[Amlodipine]


Indications & Dosage
INDICATIONS AND USAGE

1. Hypertension
NORVASC is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

2. Chronic Stable Angina NORVASC is indicated for the treatment of chronic stable angina. NORVASC may be used alone or in combination with other antianginal agents.

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3. Vasospastic Angina (Prinzmetal's or Variant Angina) NORVASC is indicated for the treatment of confirmed or suspected vasospastic angina.
NORVASC may be used as monotherapy or in combination with other antianginal drugs.

DOSAGE AND ADMINISTRATION

Adults

The usual initial antihypertensive oral dose of NORVASC is 5 mg once daily with a maximum dose of 10 mg once daily. Small, fragile, or elderly individuals, or patients with hepatic insufficiency may be started on 2.5 mg once daily and this dose may be used when adding NORVASC to other antihypertensive therapy.

Dosage should be adjusted according to each patient's need. In general, titration should proceed over 7 to 14 days so that the physician can fully assess the patient's response to each dose level. Titration may proceed more rapidly, however, if clinically warranted, provided the patient is assessed frequently.

The recommended dose for chronic stable or vasospastic angina is 5-10 mg, with the lower dose suggested in the elderly and in patients with hepatic insufficiency. Most patients will require 10 mg for adequate effect. See ADVERSE REACTIONS section for information related to dosage and side effects.

Children

The effective antihypertensive oral dose in pediatric patients ages 6-17 years is 2.5 mg to 5 mg once daily. Doses in excess of 5 mg daily have not been studied in pediatric patients. See CLINICAL PHARMACOLOGY.
Co-administration with Other Antihypertensive and/ or Antianginal Drugs: NORVASC has been safely administered with thiazides, ACE inhibitors, beta-blockers, long-acting nitrates, and/ or sublingual nitroglycerin.

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