Neurontin

[Gabapentin]

Indications & Dosage
INDICATIONS AND USAGE

Postherpetic Neuralgia
Neurontin ® (gabapentin) is indicated for the management of postherpetic neuralgia in adults.

Epilepsy
Neurontin ® (gabapentin) is indicated as adjunctive therapy in the treatment of partial seizures with and without secondary generalization in patients over 12 years of age with epilepsy.

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Neurontin is also indicated as adjunctive therapy in the treatment of partial seizures in pediatric patients age 3 – 12 years.

DOSAGE AND ADMlNlSTRATION

Neurontin ® is given orally with or without food. If Neurontin ® dose is reduced, discontinued or substituted with an alternative medication, this should be done gradually over a minimum of 1 week.

Postherpetic Neuralgia
In adults with postherpetic neuralgia, Neurontin ® therapy may be initiated as a single 300-mg dose on Day 1, 600 mg/ day on Day 2 (divided BID), and 900 mg/ day on Day 3 (divided TID).

The dose can subsequently be titrated up as needed for pain relief to a daily dose of 1800 mg (divided TID). In clinical studies, efficacy was demonstrated over a range of doses from 1800 mg/ day to 3600 mg/ day with comparable effects across the dose range. Additional benefit of using doses greater than 1800 mg/ day was not demonstrated.

Epilepsy

Neurontin ® is recommended for add-on therapy in patients 3 years of age and older. Effectiveness in pediatric patients below the age of 3 years has not been established.

Patients >12 years of age:

The effective dose of Neurontin ® is 900 to 1800 mg/ day and given in divided doses (three times a day) using 300 or 400 mg capsules, or 600 or 800 mg tablets. The starting dose is 300 mg three times a day. If necessary, the dose may be increased using 300 or 400 mg capsules, or 600 or 800 mg tablets three times a day up to 1800 mg/ day. Dosages up to 2400 mg/ day have been well tolerated in long-term clinical studies. Doses of 3600 mg/ day have also been administered to a small number of patients for a relatively short duration, and have been well tolerated. The maximum time between doses in the TID schedule should not exceed 12 hours.

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