Zestoretic

[Lisinopril/HCTZ]

Cardiovascular

Cardiac arrest, myocardial infarction or cerebrovascular accident, possibly secondary to excessive hypotension in high risk patients (see WARNINGS, Hypotension), pulmonary embolism and infarction, worsening of heart failure, arrhythmias (including tachycardia, ventricular tachycardia, atrial tachycardia, atrial fibrillation, bradycardia, and premature ventricular contractions), angina pectoris, transient ischemic attacks, paroxysmal nocturnal dyspnea, decreased blood pressure, peripheral edema, vasculitis;

Digestive

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Pancreatitis, hepatitis (hepatocellular or cholestatic jaundice) (see WARNINGS, Hepatic Failure), gastritis, anorexia, flatulence, increased salivation;

Endocrine: Diabetes mellitus;

Hematologic

Rare cases of bone marrow depression, hemolytic anemia, leukopenia/ neutropenia, and thrombocytopenia have been reported in which a causal relationship to lisinopril can not be excluded;

Metabolic

Gout, weight loss, dehydration, fluid overload, weight gain;

Musculoskeletal

Arthritis, arthralgia, neck pain, hip pain, joint pain, leg pain, arm
pain, lumbago;

Nervous System/ Psychiatric

Ataxia, memory impairment, tremor, insomnia, stroke, nervousness, confusion, peripheral neuropathy (eg, paresthesia, dysesthesia), spasm, hypersomnia, irritability;

Respiratory

Malignant lung neoplasms, hemoptysis, pulmonary edema, pulmonary infiltrates, bronchospasm, asthma, pleural effusion, pneumonia, eosinophilic pneumonitis, wheezing, orthopnea, painful respiration, epistaxis, laryngitis, sinusitis, pharyngitis, rhinitis, rhinorrhea, chest sound abnormalities;

Skin:

Urticaria, alopecia, herpes zoster, photosensitivity, skin lesions, skin infections, pemphigus, erythema, rare cases of other severe skin reactions, including toxic epidermal necrolysis and Stevens-Johnson syndrome (causal relationship has not been established);

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