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If trough response is inadequate, dividing the daily dose should be considered. If blood pressure is not adequately controlled with MONOPRIL alone, a diuretic may be added. Concomitant administration of MONOPRIL with potassium supplements, potassium salt substitutes, or potassium-sparing diuretics can lead to increases of serum potassium (see PRECAUTIONS). In patients who are currently being treated with a diuretic, symptomatic hypoten-sion occasionally can occur following the initial dose of MONOPRIL. To reduce the likelihood of hypotension, the diuretic should, if possible, be discontinued two to three days prior to beginning therapy with MONOPRIL (see WARNINGS). Then, if blood pressure is not controlled with MONOPRIL alone, diuretic therapy should be resumed. If diuretic therapy cannot be discontinued, an initial dose of 10 mg of MONOPRIL should be used with careful medical supervision for several hours and until blood pressure has stabilized. (See WARNINGS; PRECAUTIONS: Information for Patients and Drug Interactions.) Since concomitant administration of MONOPRIL with potassium supplements, or potassium-containing salt substitutes or potassium-sparing diuretics may lead to increases in serum potassium, they should be used with caution (see PRECAUTIONS). Text Continues Below
Heart Failure Digitalis is not required for MONOPRIL to manifest improvements in exercise toler-ance and symptoms. Most placebo-controlled clinical trial experience has been with both digitalis and diuretics present as background therapy. The usual starting dose of MONOPRIL should be 10 mg once daily. Following the initial dose of MONOPRIL, the patient should be observed under medical supervision for at least two hours for the presence of hypotension or orthostasis and, if present, until blood pressure stabilizes. An initial dose of 5 mg is preferred in heart failure patients with moderate to severe renal failure or those who have been vigorously diuresed. Page: << Prev | 1 | 2 | 3 | Next >>
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