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The ALTACE Capsule is usually swallowed whole. The ALTACE Capsule can also be opened and the con-tents sprinkled on a small amount (about 4 oz.) of apple sauce or mixed in 4 oz. (120 ml) of water or apple juice. To be sure that ramipril is not lost when such a mixture is used, the mixture should be consumed in its entire-ty. The described mixtures can be pre-prepared and stored for up to 24 hours at room temperature or up to 48 hours under refrigeration. Concomitant administration of ALTACE with potassium supplements, potassium salt substitutes, or potas-sium-sparing diuretics can lead to increases of serum potassium. (See PRECAUTIONS.) In patients who are currently being treated with a diuretic, symptomatic hypotension occasionally can occur following the initial dose of ALTACE. To reduce the likelihood of hypotension, the diuretic should, if possible, be discontinued two to three days prior to beginning therapy with ALTACE. (See WARNINGS.) Then, if blood pressure is not controlled with ALTACE alone, diuretic therapy should be resumed. If the diuretic cannot be discontinued, an initial dose of 1.25 mg ALTACE should be used to avoid excess hypotension. Dosage Adjustment in Renal Impairment Text Continues Below
In patients with creatinine clearance <40 ml/ min/ 1.73m 2 (serum creatinine approximately >2.5 mg/ dl) doses only 25% of those normally used should be expected to induce full therapeutic levels of ramiprilat. (See CLIN-ICAL PHARMACOLOGY.) Hypertension: For patients with hypertension and renal impairment, the recommended initial dose is 1.25 mg ALTACE once daily. Dosage may be titrated upward until blood pressure is controlled or to a maximum total daily dose of 5 mg. Heart Failure Post Myocardial Infarction: For patients with heart failure and renal impairment, the recom-mended initial dose is 1.25 mg ALTACE once daily. The dose may be increased to 1.25 mg b. i. d. and up to a maximum dose of 2.5 mg b. i. d. depending upon clinical response and tolerability. Page: << Prev | 1 | 2 | 3 | 4 | Next >>
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