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Lotensin

[Benazepril]

Pregnancy Categories C (first trimester) and D (second and third trimesters)

See WARNINGS, Fetal/ Neonatal Morbidity and Mortality.

Nursing Mothers

Text Continues Below



Minimal amounts of unchanged benazepril and of benazeprilat are excreted into the breast milk of lactating women treated with benazepril. A newborn child ingesting entirely breast milk would receive less than 0.1% of the mg/ kg maternal dose of benazepril and benazeprilat.

Geriatric Use

Of the total number of patients who received benazepril in U. S. clinical studies of Lotensin, 18% were 65 or older while 2% were 75 or older. No overall differences in effectiveness or safety were observed between these patients and younger patients, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out. Benazepril and benazeprilat are substantially excreted by the kidney. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.

Pediatric Use
Safety and effectiveness in pediatric patients have not been established.

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