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Skeletal muscle cramps, myalgia, myopathy, rhabdomyolysis, arthralgias. Neurological Text Continues Below
dysfunction of certain cranial nerves (including alteration of taste, impairment of extra-ocular movement, facial paresis), tremor, dizziness, vertigo, memory loss, paresthesia, peripheral neuropathy, peripheral nerve palsy, psychic disturbances, anxiety, insomnia, depression. Hypersensitivity Reactions An apparent hypersensitivity syndrome has been reported rarely which has included one or more of the following features: anaphylaxis, angioedema, lupus erythematous-like syndrome, polymyalgia rheumatica, dermatomyositis, vasculitis, purpura, thrombocytopenia, leukopenia, hemolytic anemia, positive ANA, ESR increase, eosinophilia, arthritis, arthralgia, urticaria, asthenia, photosensitivity, fever, chills, flushing, malaise, dyspnea, toxic epidermal necrolysis, erythema multiforme,
including Stevens-Johnson syndrome. Gastrointestinal pancreatitis, hepatitis, including chronic active hepatitis, cholestatic jaundice, fatty change in liver, and, rarely, cirrhosis, fulminant hepatic necrosis, and hepatoma; anorexia, vomiting. Skin: alopecia, pruritus. A variety of skin changes (e. g., nodules, discoloration, dryness of skin/ mucous membranes, changes to hair/ nails) have been reported. Reproductive gynecomastia, loss of libido, erectile dysfunction. Eye progression of cataracts (lens opacities), ophthalmoplegia. Laboratory Abnormalities elevated transaminases, alkaline phosphatase, -glutamyl transpeptidase, and bilirubin; thyroid function abnormalities. Laboratory Tests Marked persistent increases of serum transaminases have been noted (see WARNINGS, Liver Dysfunction). About 5% of patients had elevations of CK levels of 3 or more times the normal value on one or more occasions. This was attributable to the noncardiac fraction of CK. Muscle pain or dysfunction usually was not reported (see WARNINGS, Myopathy/ Rhabdomyolysis). Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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