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Overdosage with salmeterol may be expected to result in exaggeration of the pharmacologic adverse effects associated with beta-adrenoceptor agonists, including tachycardia and/or arrhythmia, tremor, headache, and muscle cramps. Overdosage with salmeterol can lead to clinically significant prolongation of the QTc interval, which can produce ventricular arrhythmias. Other signs of overdosage may include hypokalemia and hyperglycemia. As with all sympathomimetic medications, cardiac arrest and even death may be associated with abuse of salmeterol. Treatment consists of discontinuation of salmeterol together with appropriate symptomatic therapy. The judicious use of a cardioselective beta-receptor blocker may be considered, bearing in mind that such medication can produce bronchospasm. There is insufficient evidence to determine if dialysis is beneficial for overdosage of salmeterol. Cardiac monitoring is recommended in cases of overdosage. Text Continues Below
No deaths were seen in rats given salmeterol at an inhalation dose of 2.9 mg/kg (approximately 250 times the maximum recommended daily inhalation dose in adults on a mg/m 2 basis) and in dogs at an inhalation dose of 0.7 mg/kg (approximately 190 times the maximum recommended daily inhalation dose in adults on a mg/m 2 basis). By the oral route, no deaths occurred in mice at 150 mg/kg (approximately 6,500 times the maximum recommended daily inhalation dose in adults on a mg/m 2 basis) and in rats at 1,000 mg/kg (approximately 86,000 times the maximum recommended daily inhalation dose in adults on a mg/m 2 basis). Page: << Prev | 1 | 2
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