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Advair Diskus

[Salmeterol/Fluticasone]

For patients who are not currently on an inhaled corticosteroid, whose disease severity warrants treatment with 2 maintenance therapies, including patients on non-corticosteroid maintenance therapy, the recommended starting dosage is ADVAIR DISKUS 100/50 twice daily. For patients on an inhaled corticosteroid, Table 5 provides the recommended starting dosage. The maximum recommended dosage is ADVAIR DISKUS 500/50 twice daily.

For all patients it is desirable to titrate to the lowest effective strength after adequate asthma stability is achieved.

Table 5. Recommended Dosages of ADVAIR DISKUS for Patients With Asthma Taking Inhaled Corticosteroids

Text Continues Below



Current Daily Dose of Inhaled Corticosteroid
Recommended Strength and Dosing Schedule
of ADVAIR DISKUS
Beclomethasone dipropionate 420 mcg
462-840 mcg
100/50 twice daily
250/50 twice daily
Budesonide 400 mcg 800-1,200 mcg

1,600 mcg*
100/50 twice daily
250/50 twice daily
500/50 twice daily
Flunisolide 1,000 mcg
1,250-2,000 mcg
100/50 twice daily
250/50 twice daily
Fluticasone propionate
inhalation aerosol
176 mcg
440 mcg
660-880 mcg *

100/50 twice daily
250/50 twice daily
500/50 twice daily
Fluticasone propionate
inhalation powder
200 mcg
500 mcg
1,000 mcg *

100/50 twice daily
250/50 twice daily
500/50 twice daily
Triamcinolone acetonide 1,000 mcg
1,100-1,600 mcg
100/50 twice daily
250/50 twice daily *
ADVAIR DISKUS should not be used for transferring patients from systemic corticosteroid therapy.

ADVAIR DISKUS should be administered twice daily every day. More frequent administration (more than twice daily) or a higher number of inhalations (more than 1 inhalation twice daily) of the prescribed strength of ADVAIR DISKUS is not recommended as some patients are more likely to experience adverse effects with higher doses of salmeterol. The safety and efficacy of ADVAIR DISKUS when administered in excess of recommended doses have not been established. If symptoms arise in the period between doses, an inhaled, short-acting beta2-agonist should be taken for immediate relief. Patients who are receiving ADVAIR DISKUS twice daily should not use additional salmeterol or other inhaled, long-acting beta2-agonists (e.g., formoterol) for prevention of EIB, or for any other reason.

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