Amoxil

[amoxicillin]

S. pneumoniae S. pneumoniae should be tested using a 1-mcg oxacillin disk. Isolates with oxacillin zone sizes of . 20 mm are susceptible to amoxicillin. An amoxicillin MIC should be determined on isolates of S. pneumoniae with oxacillin zone sizes of . 19 mm. For gram-negative aerobes: Enterobacteriaceae

Zone Diameter (mm) Interpretation
. 17 Susceptible (S)
14 to 16 Intermediate (I)
. 13 Resistant (R)
H. influenzae g
Zone Diameter (mm) Interpretation
. 22 Susceptible (S)
19 to 21 Intermediate (I)
. 18 Resistant (R)

f. Staphylococci which are susceptible to amoxicillin but resistant to methicillin/ oxacillin should be considered as resistant to amoxicillin.

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g. These interpretive standards are applicable only to disk diffusion susceptibility tests with H. influenzae using Haemophilus Test Medium (HTM). 2 Interpretation should be as stated above for results using dilution techniques.
As with standard dilution techniques, disk diffusion susceptibility test procedures require the use of laboratory control microorganisms. The 10-mcg ampicillin disk should provide the following zone diameters in these laboratory test quality control strains:
Microorganism Zone diameter (mm)
E. coli ATCC 25922 16 to 22 H. influenzae ATCC 49247
h S. aureus ATCC 25923 27 to 35
Using 1-mcg oxacillin disk:
Microorganism Zone diameter (mm)
S. pneumoniae ATCC 49619 i 8 to 12

h. This quality control range is applicable to only H. influenzae ATCC 49247 tested by a disk diffusion procedure using HTM. 2

i. This quality control range is applicable to only S. pneumoniae ATCC 49619 tested by a disk diffusion procedure using Mueller-Hinton agar supplemented with 5% sheep blood and incubated in 5% CO2. Susceptibility testing for Helicobacter pylori: In vitro susceptibility testing methods and diagnostic products currently available for determining minimum inhibitory concentrations (MICs) and zone sizes have not been standardized, validated, or approved for testing H. pylori microorganisms.
Culture and susceptibility testing should be obtained in patients who fail triple therapy. If clarithromycin resistance is found, a non-clarithromycin-containing regimen should be used.

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