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Neither component in Augmentin is highly protein-bound; clavulanic acid has been found to be approximately 25% bound to human serum and amoxicillin approximately 18% bound. Amoxicillin diffuses readily into most body tissues and fluids with the exception of the brain and spinal fluid. The results of experiments involving the administration of clavulanic acid to animals suggest that this compound, like amoxicillin, is well distributed in body tissues. Microbiology Amoxicillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative microorganisms. Amoxicillin is, however, susceptible to degradation by -lactamases and, therefore, the spectrum of activity does not include organisms which produce these enzymes. Clavulanic acid is a -lactam, structurally related to the penicillins, which possesses the ability to inactivate a wide range of -lactamase enzymes commonly found in microorganisms resistant to penicillins and cephalosporins. In particular, it has good activity against the clinically important plasmid mediated -lactamases frequently responsible for transferred drug resistance. Text Continues Below
The formulation of amoxicillin and clavulanic acid in Augmentin protects amoxicillin from degradation by -lactamase enzymes and effectively extends the antibiotic spectrum of amoxicillin to include many bacteria normally resistant to amoxicillin and other -lactam antibiotics. Thus, Augmentin possesses the properties of a broad-spectrum antibiotic and a -lactamase inhibitor. Amoxicillin/ clavulanic acid has been shown to be active against most strains of the following microorganisms, both in vitro and in clinical infections as described in the INDICATIONS AND USAGE section. GRAM-POSITIVE AEROBES Staphylococcus aureus ( -lactamase and non- -lactamase producing) * Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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