Augmentin

[Amoxicillin/Clavulanate]

* Staphylococci which are resistant to methicillin/ oxacillin must be considered resistant to amoxicillin/ clavulanic acid.
GRAM-NEGATIVE AEROBES Enterobacter species (Although most strains of Enterobacter species are resistant in vitro, clinical efficacy has been demonstrated with Augmentin in urinary tract infections caused by these organisms.) Escherichia coli ( -lactamase and non- -lactamase producing) Haemophilus influenzae ( -lactamase and non- -lactamase producing) Klebsiella species (All known strains are -lactamase producing.) Moraxella catarrhalis ( -lactamase and non- -lactamase producing)

The following in vitro data are available, but their clinical significance is unknown.

Amoxicillin/ clavulanic acid exhibits in vitro minimal inhibitory concentrations (MICs) of 2 µg/ mL or less against most ( . 90%) strains of Streptococcus pneumoniae § ; MICs of 0.06 µg/ mL or less against most ( . 90%) strains of Neisseria gonorrhoeae; MICs of 4 µg/ mL or less against most ( . 90%) strains of staphylococci and anaerobic bacteria; and MICs of 8 µg/ mL or less against most ( . 90%) strains of other listed organisms. However, with the exception of organisms shown to respond to amoxicillin alone, the safety and effectiveness of amoxicillin/ clavulanic acid in treating clinical infections due to these microorganisms have not been established in adequate and well-controlled clinical trials. § Because amoxicillin has greater in vitro activity against Streptococcus pneumoniae than does ampicillin or penicillin, the majority of S. pneumoniae strains with intermediate susceptibility to ampicillin or penicillin are fully susceptible to amoxicillin.

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GRAM-POSITIVE AEROBES Enterococcus faecalis ||
Staphylococcus epidermidis ( -lactamase and non- -lactamase producing) Staphylococcus saprophyticus ( -lactamase and non- -lactamase producing)
Streptococcus pneumoniae || Streptococcus pyogenes ||
viridans group Streptococcus ||
GRAM-NEGATIVE AEROBES Eikenella corrodens ( -lactamase and non- -lactamase producing)
Neisseria gonorrhoeae || ( -lactamase and non- -lactamase producing) Proteus mirabilis || ( -lactamase and non- -lactamase producing)
ANAEROBIC BACTERIA Bacteroides species, including Bacteroides fragilis ( -lactamase and non- -lactamase producing)
Fusobacterium species ( -lactamase and non- -lactamase producing) Peptostreptococcus species || Adequate and well-controlled clinical trials have established the effectiveness of amoxicillin alone in treating certain clinical infections due to these organisms.

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