|
Aplastic anemia,
hemolytic anemia,
hemorrhage,
renal dysfunction,
toxic epidermal necrolysis,
toxic nephropathy,
prolonged prothrombin time,
positive Coombs' test,
elevated LDH,
pancytopenia,
neutropenia,
agranulocytosis. Several cephalosporins have been implicated in triggering seizures, particularly in patients with renal impairment, when the dosage was not reduced. (See DOSAGE AND ADMINIS-TRATION and OVERDOSAGE.) If seizures associated with drug therapy occur, the drug should be discontinued. Anticonvulsant therapy can be given if clinically indicated. Drug Interactions Text Continues Below
Nephrotoxicity has been reported following concomitant administration of aminoglyco-side antibiotics and cephalosporin antibiotics. Concomitant administration of probenecid doubled the AUC for cefprozil. The bioavailability of the capsule formulation of cefprozil was not affected when administered 5 minutes following an antacid. Drug/ Laboratory Test Interactions Cephalosporin antibiotics may produce a false positive reaction for glucose in the urine with copper reduction tests (Benedict's or Fehling's solution or with Clinitest ® tablets), but not with enzyme-based tests for glycosuria (e. g., Clinistix ® ). A false negative reaction may occur in the ferricyanide test for blood glucose. The presence of cefprozil in the blood does not interfere with the assay of plasma or urine creatinine by the alkaline picrate method. Carcinogenesis, Mutagenesis, and Impairment of Fertility Long term in vivo studies have not been performed to evaluate the carcinogenic potential of cefprozil. Cefprozil was not found to be mutagenic in either the Ames Salmonella or E. coli WP2 urvA reversion assays or the Chinese hamster ovary cell HGPRT forward gene mutation assay and it did not induce chromosomal abnormalities in Chinese hamster ovary cells or unscheduled DNA synthesis in rat hepatocytes in vitro. Page: << Prev | 1 | 2 | 3 | 4 | Next >>
|
.gif)
