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Aerobic gram-positive microorganisms: Enterococcus durans Staphylococcus warneri Enterococcus faecalis Streptococcus agalactiae
Listeria monocytogenes Streptococci (Groups C, D, F, and G)
Staphylococcus epidermidis viridans group Streptococci
Staphylococcus saprophyticus
NOTE: Cefprozil is inactive against Enterococcus faecium. Aerobic gram-negative microorganisms: Citrobacter diversus Proteus mirabilis Text Continues Below
Escherichia coli Salmonella spp.
Klebsiella pneumoniae Shigella spp.
Neisseria gonorrhoeae Vibrio spp.
(including -lactamase-producing strains)
NOTE: Cefprozil is inactive against most strains of Acinetobacter, Enterobacter, Morganella morganii, Proteus vulgaris, Providencia, Pseudomonas, and Serratia. Anaerobic microorganisms: Prevotella (Bacteroides) melaninogenicus Fusobacterium spp.
Clostridium difficile Peptostreptococcus spp.
Clostridium perfringens Propionibacterium acnes
NOTE: Most strains of the Bacteroides fragilis group are resistant to cefprozil. Susceptibility Tests Dilution Techniques: Quantitative methods are used to determine antimicrobial minimal inhibitory concentrations (MICs). These MICs provide estimates of the susceptibility of bacteria to antimicrobial compounds. The MICs should be determined using a standard-ized procedure. Standardized procedures are based on a dilution method 1, 2 (broth or agar) or equivalent with standardized inoculum concentrations and standardized con-centrations of cefprozil powder. The MIC values should be interpreted according to the
following criteria: MIC (µg/ mL) Interpretation
8 Susceptible (S) 16 Intermediate (I) 32 Resistant (R) A report of "Susceptible" indicates that the pathogen is likely to be inhibited if the antimicrobial compound in the blood reaches the concentrations usually achievable. A report of "Intermediate" indicates that the result should be considered equivocal, and, if the microorganism is not fully susceptible to alternative, clinically feasible drugs, the test should be repeated. This category implies possible clinical applicability in body sites where the drug is physiologically concentrated or in situations where high dosage of drug can be used. This category also provides a buffer zone which prevents small uncontrolled technical factors from causing major discrepancies in interpretation. A report of "Resistant" indicates that the pathogen is not likely to be inhibited if the antimi-crobial compound in the blood reaches the concentrations usually achievable; other therapy should be selected. Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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