Coreg

[Carvedilol]

Hypertension:

DOSAGE MUST BE INDIVIDUALIZED.

The recommended starting dose of COREG is 6.25 mg twice daily. If this dose is tolerated, using standing systolic pressure measured about 1 hour after dosing as a guide, the dose should be maintained for 7 to 14 days, and then increased to 12.5 mg twice daily if needed, based on trough blood pressure, again using standing systolic pressure one hour after dosing as a guide for tolerance. This dose should also be maintained for 7 to 14 days and can then be adjusted upward to 25 mg twice daily if tolerated and needed. The full antihypertensive effect of COREG is seen within 7 to 14 days. Total daily dose should not exceed 50 mg. COREG should be taken with food to slow the rate of absorption and reduce the incidence of orthostatic effects.

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Addition of a diuretic to COREG, or COREG to a diuretic can be expected to produce additive effects and exaggerate the orthostatic component of COREG action.

Use in Patients with Hepatic Impairment:

COREG should not be given to patients with severe hepatic impairment (see CONTRAINDICATIONS).

HOW SUPPLIED

Tablets: White, oval, film-coated tablets: 3.125 mg– engraved with 39 and SB, in bottles of 100; 6.25 mg– engraved with 4140 and SB, in bottles of 100; 12.5 mg– engraved with 4141 and SB, in bottles of 100; 25 mg– engraved with 4142 and SB, in bottles of 100. The 6.25 mg, 12. 5 mg, and 25 mg tablets are TILTAB tablets.
Store below 30° C (86° F). Protect from moisture. Dispense in a tight, light-resistant container.
3.125 mg 100's: NDC 0007-4139-20
6.25 mg 100's: NDC 0007-4140-20
12.5 mg 100's: NDC 0007-4141-20
25 mg 100's: NDC 0007-4142-20

COREG and TILTAB are registered trademarks of GlaxoSmithKline.
DATE OF ISSUANCE October 2003
©2003 GlaxoSmithKline
All rights reserved.

GlaxoSmithKline
Research Triangle Park, NC 27709

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