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Geriatric Use Controlled clinical studies of GLUCOPHAGE and GLUCOPHAGE XR did not include sufficient numbers of elderly patients to determine whether they respond differently from younger patients, although other reported clinical experience has not identified differences in responses between the
elderly and younger patients. Metformin is known to be substantially excreted by the kidney and because the risk of serious adverse reactions to the drug is greater in patients with impaired renal function, GLUCOPHAGE and GLUCOPHAGE XR should only be used in patients with normal renal function (see CONTRAINDICATIONS, WARNINGS, and CLINICAL PHARMACOLOGY: Pharmacokinetics). Because aging is associated with reduced renal function, GLUCOPHAGE (metformin hydrochloride tablets) or GLUCOPHAGE XR (metformin hydrochloride extended-release tablets) should be used with caution as age increases. Care should be taken in dose selec-tion and should be based on careful and regular monitoring of renal function. Generally, elderly patients should not be titrated to the maximum dose of GLUCOPHAGE or GLUCOPHAGE XR (see also WARNINGS and DOSAGE AND ADMINISTRATION). Text Continues Below
HOW SUPPLIED
GLUCOPHAGE ® (metformin hydrochloride tablets)
500 mg Bottles of 100 NDC 0087-6060-05
500 mg Bottles of 500 NDC 0087-6060-10
850 mg Bottles of 100 NDC 0087-6070-05
1000 mg Bottles of 100 NDC 0087-6071-11
GLUCOPHAGE 500-mg tablets are round, white to off-white, film coated tablets debossed with BMS 6060 around the periphery of the tablet on one side and 500 debossed across the face of the other side. GLUCOPHAGE 850-mg tablets are round, white to off-white, film coated tablets debossed with BMS 6070 around the periphery of the tablet on one side and 850 debossed across the face of the other side. GLUCOPHAGE 1000-mg tablets are white, oval, biconvex, film coated tablets with BMS 6071 debossed on one side and 1000 debossed on the opposite side and with a bisect line on both sides. Page: << Prev | 1 | 2 | 3 | 4 | 5 | Next >>
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