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Glucovance

[Glyburide/Metformin]

Q11. Are there other risk factors for lactic acidosis?

Your risk of developing lactic acidosis from taking GLUCOVANCE (Glyburide and Metformin HCl Tablets) is very low as long as your kidneys and liver are healthy. However, some factors can increase your risk because they can affect kidney and liver function. You should discuss your risk with your physician.

You should not take GLUCOVANCE if:

Text Continues Below



° You have chronic kidney or liver problems
° You have congestive heart failure which is treated with medications, e. g., digoxin (Lanoxin ® ) or furosemide (Lasix ® )

° You drink alcohol excessively (all the time or short-term "binge" drinking)
° You are seriously dehydrated (have lost a large amount of body fluids)
° You are going to have certain x-ray procedures with injectable contrast agents
° You are going to have surgery
° You develop a serious condition such as a heart attack, severe infection, or a stroke
° You are 80 years of age and have NOT had your kidney function tested

Q12. What are the symptoms of lactic acidosis?

Some of the symptoms include: feeling very weak, tired or uncomfortable; unusual muscle pain, trouble breathing, unusual or unexpected stomach dis-comfort, feeling cold, feeling dizzy or lightheaded, or suddenly developing a slow or irregular heartbeat.

If you notice these symptoms, or if your medical condition has suddenly changed, stop taking GLUCOVANCE tablets and call your doctor right away.
Lactic acidosis is a medical emergency that must be treated in a hospital.

Q13. What does my doctor need to know to decrease my risk of lactic acidosis?

Tell your doctor if you have an illness that results in severe vomiting, diarrhea, and/ or fever, or if your intake of fluids is significantly reduced. These situations can lead to severe dehydration, and it may be necessary to stop taking GLUCOVANCE temporarily.

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