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The effects of mixing Humalog with insulins of animal source or insulin preparations produced by other manufacturers have not been studied (see WARNINGS). If Humalog is mixed with a longer-acting insulin, such as Humulin N or Humulin U, Humalog should be drawn into the syringe first to prevent clouding of the Humalog by the longer-acting insulin. Injection should be made immediately after mixing. Mixtures should not be administered intravenously. Humalog in Combination with Sulfonylurea Agents-- In a two-month study in patients with fasting hyperglycemia despite maximal dosing with sulfonylureas (SU), patients were randomized to one of three treatment regimens; Humulin NPH at bedtime plus SU, Humalog three times a day before meals plus SU, or Humalog three times a day before meals and Humulin NPH at bedtime. The combination of Humalog and SU resulted in an improvement in HbA1c accompanied by a weight gain (see Table 2). Text Continues Below
Table 2 Results of a Two-Month Study in Which Humalog Was Added to Sulfonylurea Therapy in Patients Not Adequately Controlled on Sulfonylurea Alone. Humulin N h. s.+ SU Humalog a. c. + SU Humalog a. c. + Humulin N h. s. Randomized (n) 135 139 149 HbA1c (%) at baseline 9.9 10.0 10.0 HbA1c (%) at 2-months 8.7 8.4 8.5 HbA1c (%) change from baseline -1.2 -1.6 -1.4 Weight gain at 2-months (kg) 0.6 1.2 1.5 Hypoglycemia* (events/ mo) 0.11 0.03 0.09 Number of injections 1 3 4 Total insulin dose (U/ kg) at 2-months 0.23 0.33 0.52 a. c.-three times a day before meals, h. s.-at bedtime, SU-oral sulfonylurea agent * blood glucose 36mg/ dL or needing assistance from third party Page: << Prev | 1 | 2
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