Humalog

[Insulin Lispro]

Humalog was absorbed at a consistently faster rate than human regular insulin in healthy male volunteers given 0.2 U/ kg human regular insulin or Humalog at abdominal, deltoid, or femoral subcutaneous sites, the three sites often used by patients with diabetes. After abdominal administration of Humalog, serum drug levels are higher and the duration of action is slightly shorter than after deltoid or thigh administration (see DOSAGE AND ADMINISTRATION). Humalog has less intra-and inter-patient variability compared to human regular insulin.

Figure 2 Serum Humalog and Insulin levels after subcutaneous injection of human regular insulin or Humalog (0.2 U/ kg) immediately before a high carbohydrate meal in 10 patients with type 1 diabetes.*

*Baseline insulin concentration was maintained by infusion of 0. 2 mU/ min/ kg human insulin.

Text Continues Below

---

Distribution--

The volume of distribution for Humalog is identical to that of human regular insulin, with a range of 0.26-0.36 L/ kg.

Metabolism--

Human metabolism studies have not been conducted. However, animal studies indicate that the metabolism of Humalog is identiccal to that of human regular insulin.

Elimination--

When Humalog is given subcutaneously, its t1/ 2 is shorter than that of human regular insulin (1 vs 1.5 hours, respectively)). When given intravenously, Humalog and human regular insulin show identical dose-dependent elimination, with a t1/ 2 of 26 and 52 minutes at 0.1 U/ kg and 0.2 U/ kg, respectively.

Pharmacodynamics--

Studies in normal volunteers and patients with diabetes demonstrated that Humalog has a more rapid onset of glucose-lowering activity, an earlier peak for glucose lowering, and a shorter duration of glucose-lowering activity than human regular insulin (Figure 3). The earlier onset of activity of Humalog is directly related to its more rapid rate of absorption. The time course of action of insulin and insulin analogs such as Humalog may vary considerably in different individuals or within the same individual. The parameters of Humalog activity (time of onset, peak time, and duration) as designated in Figure 3 should be considered only as general guidelines. The rate of insulin absorption and consequently the onset of activity is known to be affected by the site of injection, exercise, and other variables (see PRECAUTIONS, General).

Page:  << Prev | 1 | 2 | 3 | 4 | 5 | Next >>